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Lipoarabinomannan (LAM) biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
GDP-mannose + 2-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol <=> 2-O-(6-O-acyl-alpha-D-mannosyl)-6-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol + GDP + H+ 2.4.1.346 phosphatidyl-myo-inositol dimannoside synthase

GDP-mannose + Triacylated_phosphatidyl-myo-inositol_dimannoside <=> GDP + Triacylated_phosphatidyl-myo-inositol_trimannoside 2.4.1

beta-D-mannosylphosphodecaprenol + Tetraacylated_phosphatidyl-myo-inositol_tetramannoside <=> trans,octacis-decaprenyl_phosphate + Tetraacylated_phosphatidyl-myo-inositol_pentamannoside 2.4.1

acyl-CoA + 2-O-(alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol <=> 2-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA 2.3.1.265 phosphatidylinositol dimannoside acyltransferase

beta-D-mannosylphosphodecaprenol + Triacylated_phosphatidyl-myo-inositol_tetramannoside <=> trans,octacis-decaprenyl_phosphate + Triacylated_phosphatidyl-myo-inositol_pentamannoside 2.4.1

acyl-CoA + 2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol <=> 2-O-(6-O-acyl-alpha-D-mannosyl)-6-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol + CoA 2.3.1.265 phosphatidylinositol dimannoside acyltransferase

GDP-mannose + 2-O-(alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol <=> 2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol + GDP + H+ 2.4.1.346 phosphatidyl-myo-inositol dimannoside synthase

GDP-mannose + phosphatidylinositol <=> 2-O-(alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H+ 2.4.1.345 phosphatidyl-myo-inositol alpha-mannosyltransferase

GDP-mannose + Tetraacylated_phosphatidyl-myo-inositol_dimannoside <=> GDP + Tetraacylated_phosphatidyl-myo-inositol_trimannoside 2.4.1

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